The South Dakota School of Mines & Technology will host the third Conference on Science at the Sanford Underground Research Facility to address scientific research related to the laboratory in nearby Lead, SD. Scientists from around the world are conducting the MAJORANA DEMONSTRATOR project, LUX-ZEPLIN (LZ), CASPAR, SIGMA-V, and other experiments in geology, biology, and engineering. The laboratory will also soon be the home of the Deep Underground Neutrino Experiment (DUNE). Scientific topics of the conference include: Neutrino Oscillations, Supernova Neutrinos, Proton Decay, Nuclear Astrophysics, Dark Matter, Neutrinoless Double Beta Decay, Materials Science for Nuclear and Particle Physics, Geology, and Astrobiology and Life in Extreme Environments. The conference will open on Wednesday, May 15 and close at noon on Friday, May 17, 2019. Plenary sessions on the conference topics will be held in the morning followed by dedicated parallel sessions in the afternoon. A satellite workshop on Low-Background techniques for Dark Matter and Neutrino Physics will be organized on Tuesday, May 14, 2019. Tours of the Underground Science areas of the Sanford Underground Research Facility will be available as part of the conference.